Evidence map›Paper›PMID 41476984›Full record

ArticleFrontiers in immunology2025

Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL.

Qirui Zhou, Ruinan Jia, Jinlin Chen, Yang Tan, Yuechan Ma, Mengfan Luan, Xue Sheng, Xiao Han, Shuying Li, Fei Lu and 3 more

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Qirui Zhou *Department of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ruinan Jia *Department of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Jinlin ChenDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yang TanDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yuechan MaDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Mengfan LuanDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xue ShengDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiao HanDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shuying LiDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Fei LuDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Chunyan JiDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Dongmei WangShandong Key Laboratory of Hematological Diseases and Immune Microenvironment, Qilu Hospital of Shandong University, Shandong University, Jinan, China.
Jingjing YeDepartment of Hematology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm characterized by diverse gene expression profiles and genetic alterations, resulting in substantial variations in clinical features and response to therapy. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a central role in innate immune response and affects the development of DLBCL. However, the relationship between genetic polymorphisms in genes involved in the cGAS-STING-mediated signaling pathway and their role in DLBCL remains underexplored. Methods: A total of 147 patients with DLBCL and 247 healthy controls were recruited. Single nucleotide polymorphism (SNP) genotyping was conducted using the MassARRAY platform. We evaluated the associations between the selected SNPs and DLBCL susceptibility, clinical features, and survival. Results: In our study, TREX1 rs11797 and CXCL10 rs4508917 showed significant association with DLBCL susceptibility. IFNB1 rs1051922 was correlated with white blood cell (WBC) and monocyte count at diagnosis. TREX1 rs11797 and IFNB1 rs1051922 were associated with chemotherapy response in DLBCL. Moreover, PRMT1 rs975484 and CXCL10 rs8878 were associated with the overall survival of patients with DLBCL. Notably, PRMT1 rs975484 was also correlated with hemoglobin (HGB) level, and may serve as an independent favorable prognostic factor in DLBCL. Conclusions: Our findings suggest that SNPs involved in cGAS-STING-mediated type I interferon pathway may influence DLBCL susceptibility, treatment response, and prognosis, highlighting their potential as biomarkers for risk stratification and for guiding individualized disease monitoring.

Indexed as

Immunity, InnateInterferon Type ILymphoma, Large B-Cell, DiffuseMembrane ProteinsNucleotidyltransferasesPolymorphism, Single NucleotideSignal TransductionAdultAgedCase-Control StudiesChemokine CXCL10Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseExodeoxyribonucleasesFemaleGenetic Predisposition to DiseaseGenotypecGAS protein, humanChemokine CXCL10CXCL10 protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseExodeoxyribonucleasesInterferon Type IMembrane ProteinsNucleotidyltransferasesPhosphoproteinsSTING1 protein, humanSTING Proteinthree prime repair exonuclease 1DLBCLinnate immuneprognosisSNPstreatment response

Identifiers

PMID41476984
PMCPMC12747902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.