Evidence map›Paper›PMID 41476971›Full record

ArticleFrontiers in immunology2025

Native C3 is activated without proteolytic cleavage by transformation to C3(H

David Eikrem, Vivek A Manivel, Jacob Whittaker, Osama A Hamad, Camilla Mohlin, Anna Adler, Claudia Dührkop, Roland Ebert, Yuji Teramura, Kristina N Ekdahl and 2 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David Eikrem *Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Vivek A Manivel *Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Jacob WhittakerDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Osama A HamadDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Camilla MohlinLinnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
Anna AdlerDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Claudia DührkopDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Roland EbertDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Yuji TeramuraDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Kristina N EkdahlDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Karin Fromell *Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Bo Nilsson *Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-over of C3 to fluid-phase C3(H

Indexed as

Blood PlateletsCell MembraneComplement C3PhospholipidsComplement C3bEndothelial CellsHumansLiposomesNeutrophilsPlatelet ActivationProtein BindingProteolysisComplement C3Complement C3bLiposomesPhospholipidsalternative pathway activationC3(H2O)contact activationnative C3non-proteolyticalphospholipid-scrambled cell membranes

Identifiers

PMID41476971
PMCPMC12747956

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.