ArticleFrontiers in clinical diabetes and healthcare2025
Real-world effectiveness and safety of imeglimin: a single-center retrospective cohort study in Japan.
Article in Frontiers in clinical diabetes and healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Durability and Safety of Imeglimin as an Add-On to DPP-4 Inhibitors in Japanese Type 2 Diabetes: The 104-Week FAMILIAR Trial.Diabetes, obesity & metabolism · 2026Trial
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11 authors.
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Abstract
Aims/Introduction: This study aimed to evaluate the real-world effectiveness and safety of imeglimin in individuals with type 2 diabetes. Materials and methods: We retrospectively reviewed 79 individuals (52 men, 27 women) with type 2 diabetes who newly initiated imeglimin (1,000 mg twice daily) and were followed for 12 months at the Central Japan International Medical Center between September 2022 and December 2023. Individuals were stratified by age (<65, 65-74, ≥75 years) and by the presence or absence of biguanide dose reduction at imeglimin initiation. The primary endpoint was the change in HbA1c from baseline to 12 months. Secondary endpoints included the achievement rate of glycemic targets, incidence of adverse events, and changes in body weight, blood pressure, liver and renal function, lipid profile, and uric acid. Results: HbA1c significantly decreased one month after initiation and the improvement was sustained through 12 months (mean change from baseline -0.8 ± 1.2%). Effectiveness and safety did not differ significantly among age groups. Gastrointestinal symptoms were the most common adverse events (21.5%), with no age-related differences. HbA1c reduction was greater in individuals without biguanide dose reduction compared with those with dose reduction (-1.5 ± 1.7% Conclusions: Imeglimin demonstrated sustained glycemic effectiveness and favorable tolerability in real-world practice, including among elderly individuals with type 2 diabetes. These findings suggest imeglimin as a valuable therapeutic option for older adults with type 2 diabetes. Caution is warranted when co-administered with high-dose metformin, whereas combination with <1,000 mg/day appears relatively safe.
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