ArticleResearch and practice in thrombosis and haemostasis2025
Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Fibrinogen Concentrate in Acute Hemorrhage: Mechanistic Insight, Thresholds, and Targeted Replacement.Journal of clinical medicine · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: A rapid point-of-care test to measure fibrinogen levels is crucial to adequately treat major blood loss, eg, because of trauma, postpartum hemorrhage, or major surgery. Obtaining results from current fibrinogen assays is too time-consuming in emergency situations. We have developed mathematical methods to infer fibrinogen concentrations from the turbidity waveforms of the thrombin generation (TG), prothrombin time (PT), and Reptilase time (RT) assays. Objectives: The aim of this study was to verify the performance of these methods using assay waveforms from real-world patient samples. Methods: We measured TG, PT, and RT in 44 plasma samples with a wide range of fibrinogen levels (1.1-16.6 g/L), high D-dimer, prolonged PT, and/or containing anticoagulant medication. Results: Overall, data from the PT (R = 0.965) and RT (R = 0.985) assays could be used as data input to accurately infer fibrinogen levels for all patients. The TG assay (R = 0.917) was less robust and generated results for only 36 patients. Conclusion: Our mathematical methods proved to be able to accurately infer a wide range of fibrinogen levels in real-world patient samples, even in the presence of anticoagulant medication. With this study, we took the first step toward the development of a new, rapid point-of-care fibrinogen test.
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