Evidence map›Paper›PMID 41476864›Full record

ArticleCardiology research and practice2025

TBL1XR1 Promotes Coronary Artery Disease by Regulating Triglyceride Metabolism via the PPAR Pathway.

Liping Yang, Liyuan Tang, Wenping Gao, Shanshan Zhu, Jiandi Liu, Yuhui He, Fanbo Meng

Abstract read
In one paragraph

Article in Cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liping YangDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0000-0002-9859-5414
Liyuan TangDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0009-0002-9895-4111
Wenping GaoDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0009-0007-6121-7800
Shanshan ZhuDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0009-0002-1752-935X
Jiandi LiuDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0009-0007-8924-5619
Yuhui HeDepartment of Geriatric Medicine, The Second People's Hospital of Futian District, Shenzhen, 518049, Guangdong, China.ORCID https://orcid.org/0009-0002-4130-138X
Fanbo MengDepartment of Cardiology, The China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China, jlu.edu.cn.ORCID https://orcid.org/0000-0002-1356-445X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Transducin beta-like 1 X-linked receptor 1 (TBL1XR1) is significantly upregulated in the peripheral blood of patients with coronary artery disease (CAD). This study aimed to validate the differential expression of TBL1XR1 in CAD and investigate its role in CAD progression using RNA interference. Methods: The expression of TBL1XR1 at the mRNA and protein levels was detected in patients with CAD and controls using reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. Additionally, the effects of Results: TBL1XR1 expression was significantly higher in the peripheral blood of CAD patients compared to controls at both mRNA (1.71 ± 0.96 vs. 1.00 ± 0.34, Conclusion:

Indexed as

coronary artery diseasePPAR pathwayTBL1XR1triglyceride

Identifiers

PMID41476864
PMCPMC12752874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.