ReviewACS central science2025
The Rise and Promise of Macrocyclic Hosts in Biomedicine.
Review in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Coupling photodynamic hypoxia amplification with a self-reporting chemiluminescent prodrug for adaptive precision therapy.Materials today. Bio · 2026Article
- Guest-dependent solid-state superstructure plasticity and its application to adsorptive benzene sieving.Chemical science · 2026Article
- Boosting cancer therapy with self-assembled inorganic nanocarriers via host-guest chemistry.Materials today. Bio · 2026Review
- Carbene-catalyzed double esterification enables enantioselective conformational self-locking of pillar[5]arenes.Nature communications · 2026Article
- Novel macrocycles: from synthesis to supramolecular function.Beilstein journal of organic chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrocyclic hosts, possessing cyclic structures capable of encapsulating other molecules and ions, have exhibited unique characteristics in biomedical applications. Having preorganized cavities, macrocyclic hosts can monitor, intervene in, and simulate biological processes by complexing with bioactive substances. Additionally, the framework of macrocyclic hosts can exhibit remarkable efficacy in some applications such as transmembrane transport and antimicrobial. In this Outlook, we expressed some of our personal insights on the distinctive aspects of macrocyclic hosts in biomedical applications, highlighting some examples in disease diagnosis and treatment to provide illustrations. We also discussed the future opportunities and challenges of macrocyclic hosts in biomedical applications along with some suggestions on how to overcome these challenges. Considering the progress we have witnessed in the past decade, we believe that the future of this field is very bright.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.