ReviewMaterials today. Bio2026
PRP-related biomaterials enhance bone and nerve repair.
Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biofunctionalization of mineralized collagen with platelet-rich plasma enhances osteogenesis in critical-sized bone defects.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone and nerve injuries are the most common problems in orthopedic trauma, so orthopedic researchers are committed to studying efficient and economical strategies for repairing bone defects and nerve injuries. Platelet-rich plasma (PRP) is a self-derived blood derivative rich in growth factors and bioactive components, which plays a key role in promoting bone defect repair and nerve regeneration, and can effectively cope with the clinical problem of marginal bone defect with nerve injury. However, the explosive release of growth factors in PRP affects its practical use, and the controllable release of growth factors on demand can effectively enhance its efficiency in bone and nerve repair. In this paper, the application and mechanism of PRP reinforced biomaterials in bone and nerve regeneration are systematically reviewed. In the process of bone regeneration, PRP can promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), induce type H angiogenesis, and promote the regeneration of vascularized bone. In the field of nerve repair, PRP can promote the regeneration of peripheral and central nerve injury sites, stimulate the synthesis of new connective tissue and vascular reconstruction, down-regulate pro-inflammatory factors to build anti-inflammatory microenvironment and reduce nerve cell damage.To sum up, this study deeply discussed the mechanism of PRP in bone and nerve repair, and elaborated various advanced multifunctional biomaterials to solve the explosive release problem of PRP in use, providing theoretical basis for the standardized application and clinical transformation of PRP.
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