Evidence map›Paper›PMID 41476724›Full record

ArticleJournal of the Endocrine Society2026

Improving MASLD Risk Stratification in Young Adults with Cardiometabolic Risk Factors and Insulin Resistance Assessment.

Anu Sharma, Eddison Godinez Leiva, Srilaxmi Kalavalapalli, Andrea Ortiz Rocha, Nathaly Cuervo-Pardo, Jens Rosenberg, Pierre Bedossa, Romina Lomonaco, Fernando Bril, Diana Barb and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anu SharmaDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID https://orcid.org/0000-0002-0435-2201
Eddison Godinez LeivaDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Srilaxmi KalavalapalliDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Andrea Ortiz RochaDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Nathaly Cuervo-PardoDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Jens RosenbergAdvanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Pierre BedossaDepartment of Pathology, Hôspital Beaujon, AP-HP Nord, Clichy 92110, France.
Romina LomonacoDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Fernando BrilDivision of Endocrinology, Diabetes and Metabolism, University of Alabama, Birmingham, AL 35294, USA.
Diana BarbDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Kenneth CusiDivision of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID https://orcid.org/0000-0002-8629-418X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: The fibrosis-4 index (FIB-4) index is recommended to identify adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and clinically significant fibrosis (moderate to advanced fibrosis or ≥F2). However, it is less reliable in young adults (age <45 years). Objective: The aim was to assess whether cardiometabolic risk factors [CMRFs: type 2 diabetes (T2D), hypertension, obesity] or insulin resistance (IR) improved MASLD fibrosis risk stratification in young adults. Methods: Adults with/without T2D and no history of MASLD attending outpatient clinics underwent screening with vibration-controlled transient elastography for ≥F2 (liver stiffness measurement ≥ 8.0 kPa). Magnetic resonance elastography and/or liver biopsy were performed if indicated for diagnosis confirmation. Results: Of the 964 adults, 25% were young adults and 75% were 45 to 64 years, with the prevalence of ≥F2: 7% vs 9% ( Conclusion: In young adults, the absence of CMRFs or IR makes clinically significant fibrosis unlikely. Measuring IR improved risk stratification in young adults with CMRFs. Using CMRFs with IR may improve the detection of clinically significant fibrosis in young adults.

Indexed as

cardiometabolic risk factorsdiabetes mellitus type 2MASLD/NAFLDobesityyoung adults

Identifiers

PMID41476724
PMCPMC12748938

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.