ArticleBJA open2025
Chronic kidney disease progression after cardiac surgery: a retrospective multicentre study.
Article in BJA open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic kidney disease (CKD) is a well-established risk factor for adverse outcomes after cardiac surgery. However, the long-term trajectory of kidney function in this high-risk group remains poorly characterised. This study's primary aim was to describe CKD progression and kidney failure in patients with kidney impairment before cardiac surgery. The secondary aim was to evaluate the impact of preexisting CKD in association with known risk factors (age, sex, and postoperative acute kidney injury) on CKD disease progression after cardiac surgery. Methods: This retrospective observational multicentre study included adult patients who underwent cardiac surgery at the Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, between 2000 and 2022, and the Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, between 2008 and 2024. Three outcomes were assessed, according to Kidney Disease: Improving Global Outcomes (KDIGO): rapid progression (confirmed estimated glomerular filtration rate [eGFR] decline ≥5 ml min Results: Among 27 483 adult cardiac surgery patients, 3512 patients (12.8%) had preexisting CKD (KDIGO stages G3a-G5), based on preoperative eGFR levels. Five-year survival decreased with worsening baseline kidney function: 86.1% in stages G1-2, 70.6% in stage G3a, 61.4% in stage G3b, 45.7% in stage G4, and 51.9% in stage G5. Cumulative 5-yr incidence was 38.7% for rapid progression, 23.8% for CKD stage progression, and 5.5% for kidney failure. Events clustered early post discharge, with 43% of rapid progression, 26% of kidney failure, and 18% of CKD progression events occurring within the first year. Males aged ≤70 yr with stage G4 CKD who developed postoperative acute kidney injury faced highest risks across all outcomes. Conclusions: Cardiac surgery patients with preexisting CKD face substantial kidney disease progression, especially early after discharge. These findings highlight the need for research into structured follow-up programmes and kidney-preventive interventions.
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