ArticleJournal of geriatric cardiology : JGC2025
Frailty index changes before and after incident cardiovascular disease.
Article in Journal of geriatric cardiology : JGC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypertension and frailty in older adults: a bibliometric analysis and knowledge mapping based on Web of Science, Scopus, and PubMed (1973-2025).Frontiers in medicine · 2026Pooled it
- CRT upgrade improves frailty status in patients with HFrEF and RV pacing-a post hoc analysis of the BUDAPEST-CRT trial.GeroScience · 2026Article
- Relationship Between Internet Use Purposes and Depressive Symptoms Among Chinese Older Adults: A Cross-Lagged Panel Network Analysis.Depression and anxiety · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiovascular disease (CVD) and frailty are interrelated conditions prevalent in aging populations, yet their dynamic temporal relationship remains underexplored. This study investigates longitudinal changes in frailty trajectories before and after incident CVD across diverse cohorts. Methods: Utilizing data from four longitudinal, multinational cohorts (ELSA, HRS, CHARLS, SHARE; Results: Frailty increased steadily before CVD onset (pre-CVD slope: ELSA β = 0.005, HRS β = 0.005, CHARLS β = 0.012, SHARE β = 0.007; all Conclusions: This first multinational study demonstrates bidirectional acceleration of frailty around CVD onset, highlighting their close temporal interplay. These findings suggest that incorporating frailty assessment into CVD management may help identify high-risk individuals and support timely, multidimensional care in aging populations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.