ArticleJournal of geriatric cardiology : JGC2025
Unmasking frailty in coronary artery disease: impact on outcomes after lower limb amputation.
Article in Journal of geriatric cardiology : JGC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Frailty is a major determinant of outcomes in patients with coronary artery disease (CAD) undergoing lower limb amputation. This study evaluates the impact of frailty on in-hospital outcomes in these patients. Methods: We performed a retrospective analysis of the National Inpatient Sample (2016-2021) to identify adult patients with CAD who underwent lower limb amputation. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups (ACG) frailty indicator. Multivariable logistic regression was used to assess the independent association of frailty with in-hospital outcomes, and propensity score matching (PSM) was performed to further account for confounding factors. Results: After PSM, 9,990 patients were included in each cohort. Frail patients experienced higher rates of in-hospital mortality (3.9% Conclusion: Frailty is independently associated with increased in-hospital mortality and adverse events among CAD patients undergoing lower limb amputation. Incorporating frailty assessment into preoperative evaluation may improve risk stratification and guide clinical decision-making in this high-risk population.
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