Evidence map›Paper›PMID 41476656›Full record

ArticleExploration (Beijing, China)2025

A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors.

Yu-Jia Wang, Wen-Jie Jiang, Hua-Jun Zhao, Jian-Qun Deng, Yi-Min Cai, Yi Li, Xiao-Lin Meng, Jin Hou, Feng-Shan Wang, Ju-Zheng Sheng

Abstract read
In one paragraph

Article in Exploration (Beijing, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu-Jia WangSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Wen-Jie JiangSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Hua-Jun ZhaoInstitute of Immunopharmaceutical Sciences School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University Jinan China.
Jian-Qun DengSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Yi-Min CaiSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Yi LiSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Xiao-Lin MengSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Jin HouThe State Key Laboratory of Microbial Technology Shandong University Qingdao China.
Feng-Shan WangSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.
Ju-Zheng ShengSchool of Pharmaceutical Sciences Cheeloo College of Medicine Key Laboratory of Chemical Biology of Natural Products (Ministry of Education) Shandong University Jinan China.ORCID https://orcid.org/0000-0003-2856-9162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid advances in synthetic biology are driving the development of microbes as therapeutic agents. While the immunosuppressive tumor microenvironment creates a favorable niche for the systematic delivery of bacteria and therapeutic payloads, these can be harmful if released into healthy tissues. To address this limitation, we designed a spatiotemporal targeting system for engineered

Indexed as

bioengineered hydrogelslong‐term antitumor protectionspatiotemporal localization of therapeutic bacteria

Identifiers

PMID41476656
PMCPMC12752581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.