ArticleExploration (Beijing, China)2025
Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C-Mediated SMAD3 mRNA Stability.
Abstract read
In one paragraph
Article in Exploration (Beijing, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of vitamin K in the prognosis of patients with hepatocellular carcinoma: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- The functions, mechanisms and clinical relevance of RNA and protein acetyltransferase NAT10: a comprehensive review.Cell biology and toxicology · 2026Review
- Depletion of NAT10 in T cells attenuates metabolic dysfunction-associated steatohepatitis in mice.Hepatology communications · 2026Article
- An ac4C-CDK4 regulatory axis driven by NAT10 sustains proliferative signaling in colorectal cancer.Translational oncology · 2026Article
- NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing.Clinical and translational medicine · 2026Article
- Targeting oncogenic NTSR1 with liensinine reprograms Gq-mediated signaling to suppress lung adenocarcinoma.Chinese medicine · 2026Article
- RNA N4-acetylcytidine modification in human cancers: from molecular function to oncogenic mechanisms.iScience · 2026Review
- Identification of a Prognostic Gene Signature Based on Lenvatinib Resistance in Hepatocellular Carcinoma with Functional Validation of the Key Gene CPB2.Journal of hepatocellular carcinoma · 2026Article
- Nutrient Restriction Improves the Therapeutic Efficacy of Sorafenib by Inducing Ferroptosis via the NRF2/HO-1/GPX4 Pathway in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Article
- Predicting the Impact of ARHGAP33 Gene on Liver Cancer Prognosis Based on Multi-Algorithm Model.International journal of general medicine · 2026Article
- Pathologic Complete Response to Neoadjuvant Dual Checkpoint Blockade with Durvalumab Plus Tremelimumab in Advanced-Stage HCC: A Case Report.Journal of hepatocellular carcinoma · 2026Article
- The Impact of Spatiotemporal Patterns of Tumor Recurrence on Prognosis in Hepatocellular Carcinoma Patients Undergoing Surgery After Conversion Therapy.Journal of hepatocellular carcinoma · 2026Article
- Etiology-Driven Mouse Models of Hepatocellular Carcinoma: Paving the Way for Precision Oncology.Journal of hepatocellular carcinoma · 2026Review
- Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C-Mediated SMAD3 mRNA Stability.Exploration (Beijing, China) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Yigan ZhangInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.ORCID https://orcid.org/0009-0004-5435-1292
Yanbin DongDepartment of Pathology The Affiliated Lianyungang Hospital of Xuzhou Medical University The First People's Hospital of Lianyungang Lianyungang China.
Shuwen ChenInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.
Hao DengHubei Key Laboratory of Tumor Microenvironment and Immunotherapy College of Basic Medical Science China Three Gorges University Yichang P. R. China.
Weiru YuKey Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University Beijing China.
Bonan ChenDepartment of Anatomical and Cellular Pathology State Key Laboratory of Translational Oncology Sir Y. K. Pao Cancer Center Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China.
Minjie ChenDepartment of Hepatobiliary Pancreatic Surgery Affiliated Taihe Hospital Hubei University of Medicine Shiyan City Hubei Province China.
Wanglong LiuSchool of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical University Wenzhou China.
Xiao TanHubei Key Laboratory of Tumor Microenvironment and Immunotherapy College of Basic Medical Science China Three Gorges University Yichang P. R. China.
Jiaxin NiInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.
Daniel RigdenDepartment of Biochemistry Cell and Systems Biology Institute of Systems Molecular and Integrative Biology University of Liverpool Liverpool UK.
Xuan WangDepartment of Biochemistry Cell and Systems Biology Institute of Systems Molecular and Integrative Biology University of Liverpool Liverpool UK.
Wuhua ZhouDepartment of Hepatobiliary Pancreatic Surgery Affiliated Taihe Hospital Hubei University of Medicine Shiyan City Hubei Province China.
Jia MengInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.
Juan ChenKey Laboratory of Precision Nutrition and Food Quality Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0009-0003-9792-7995
Yuanchao XueInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.
Zhongji MengInstitute of Biomedical Research Department of Infectious Diseases Regulatory Mechanism and Targeted Therapy for Liver Cancer, Shiyan Key Laboratory Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer Taihe Hospital (First Clinical College of Medicine) Hubei University of Medicine Shiyan Hubei China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is characterized by high morbidity and mortality, with limited effective treatment options.
Indexed as
liver cancerRNA ac4C modificationtargeted drug development
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.