Evidence map›Paper›PMID 41476632›Full record

ArticleIDCases2026

Unmasking pulmonary actinomycosis: A diagnostic challenge in a young immunocompetent male.

Ramez Othman, Diaa Shosha, Lina Alansari, Fares Aljohani, Nabih Alansari, Abdukhaliq Alghamdi, Yousef Alsharhan, Mikqdad Alsaeed, Alaa Alibrahim, Shahad Alshehri and 2 more

Abstract readCase Reports
In one paragraph

Article in IDCases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramez OthmanMedicine Department, Infectious Diseases Unit, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Diaa ShoshaMedicine Department, Infectious Diseases Unit, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Lina AlansariMedicine Department, Infectious Diseases Unit, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Fares AljohaniMedicine Department, Infectious Diseases Unit, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Nabih AlansariMedicine Department, Infectious Diseases Division, Prince Sultan Military Medical City, Ministry of Defence Health Services General Directorate, Riyadh, Saudi Arabia.
Abdukhaliq AlghamdiMedicine Department, Infectious Diseases Division, Prince Sultan Military Medical City, Ministry of Defence Health Services General Directorate, Riyadh, Saudi Arabia.
Yousef AlsharhanMedicine Department, Infectious Diseases Division, Prince Sultan Military Medical City, Ministry of Defence Health Services General Directorate, Riyadh, Saudi Arabia.
Mikqdad AlsaeedMedicine Department, King Saud Medical City, Riyadh, Saudi Arabia.
Alaa AlibrahimMedicine Department, Infectious Diseases, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Shahad AlshehriMedicine Department, Dr. Suliman Alhabib Medical Group, Riyadh, Saudi Arabia.
Sirine AhmadMedicine Department, Dr. Suliman Alhabib Medical Group, Riyadh, Saudi Arabia.
Mohammed AlsaeedMedicine Department, Infectious Diseases Division, Prince Sultan Military Medical City, Ministry of Defence Health Services General Directorate, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary actinomycosis is a rare, indolent infection that frequently mimics pulmonary tuberculosis, malignancy, or chronic fungal disease, resulting in delayed diagnosis-particularly in regions where tuberculosis and aspergillosis are endemic. Case Presentation: A 33-year-old immunocompetent male presented with four months of fever, night sweats, weight loss, and progressive dry cough, followed by massive hemoptysis. Chest CT showed a cavitary right upper lobe lesion with an intracavitary ball-like component suggesting aspergilloma. Extensive microbiological investigations for tuberculosis, fungal infection, and other pathogens were negative. Due to massive hemoptysis and diagnostic uncertainty, the patient underwent VATS resection. Histopathology confirmed pulmonary actinomycosis, showing PAS-D-positive filamentous aggregates consistent with Conclusions: This case highlights the diagnostic complexity of pulmonary actinomycosis in young immunocompetent individuals, the importance of considering it among TB and fungal mimics, and the crucial role of surgical biopsy for definitive diagnosis in complex presentations.

Indexed as

ActinomycosisChronic pulmonary infectionsHemoptysisPulmonary actinomycosisTuberculosis mimics

Identifiers

PMID41476632
PMCPMC12752744

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.