ArticleFrontiers in cell and developmental biology2025
Multi-omics analysis reveals a protective role of endogenous proline in sheep oocyte vitrification and its therapeutic application.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
Introduction: Vitrification is a rapid-cooling cryopreservation technique for oocytes and a key method in assisted reproductive technology (ART). During vitrification, oocytes are exposed to high concentrations of cryoprotectants, leading to cryoinjury and osmotic stress that impair oocyte quality and subsequent developmental competence in mammals. However, the complex molecular stress responses evoked by vitrification remain poorly understood. Methods: Here, we used sheep oocytes to compare metabolome and transcriptome profiles before and after vitrification. Results: Integrated multi-omics revealed a significant accumulation of the osmoprotectant proline in vitrified oocytes. The upregulation of Conclusion: These protective effects collectively enhanced the developmental competence of vitrified sheep oocytes.
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