Evidence map›Paper›PMID 41476541›Full record

ArticleACS omega2025

Coumarin-1,2,3-Triazole Conjugates as Molecular Scaffolds for the Selective Induction of ROS-Driven Apoptosis in Cancer Cells in the Development of Pyruvate Kinase M2 Inhibitors.

Gabriel Ouverney, Amanda de Andrade Borges, Acácio Souza da Silva, Caroline Reis Santiago Paschoal, Paula Alvarez Abreu, Analice Gonçalves Rodrigues da Cruz, Mateus de Freitas Brito, Lucas Silva Abreu, Vitor Francisco Ferreira, Fernando de Carvalho da Silva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gabriel OuverneyGraduate Program in Morphological Sciences, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Fundão, Rio de Janeiro, RJ 21941-902, Brazil.
Amanda de Andrade BorgesDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.
Acácio Souza da SilvaDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.
Caroline Reis Santiago PaschoalInstitute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro, Macaé, RJ 27965-045, Brazil.
Paula Alvarez AbreuInstitute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro, Macaé, RJ 27965-045, Brazil.
Analice Gonçalves Rodrigues da CruzDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.
Mateus de Freitas BritoDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.
Lucas Silva AbreuDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.ORCID https://orcid.org/0000-0001-5620-8095
Vitor Francisco FerreiraDepartment of Pharmaceutical Technology, School of Pharmacy, Fluminense Federal University, Niterói, RJ 24020-141, Brazil.
Fernando de Carvalho da SilvaDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.ORCID https://orcid.org/0000-0002-2042-3778
Bruno Kaufmann RobbsDepartment of Basic Science, Nova Friburgo University Campus, Fluminense Federal University, Nova Friburgo, RJ 28625-650, Brazil.
Luana da Silva Magalhães ForeziDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Valonguinho Campus, Niterói, RJ 24020-150, Brazil.ORCID https://orcid.org/0000-0002-7657-4268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing incidence of cancer and the emergence of drug resistance underscore the urgent need for new therapeutic options. This study aimed to synthesize and evaluate new coumarin-triazole hybrids for their cytotoxic selectivity and safety profile, providing insights into their potential as anticancer scaffolds. Twelve novel coumarin-based compounds were obtained in good yields (40-80%) and evaluated through

Identifiers

PMID41476541
PMCPMC12750388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.