Evidence map›Paper›PMID 41476515›Full record

ArticleACS omega2025

Hydroxycarbamide and Sickle Cell Anemia: Paradoxical Effects Related to Redox Mechanisms of Cellular Adaptation.

Ilana Luize Rocha Santana, Victoria Simões Bernardo, Edis Belini Junior, Pâmela Lourdes Pereira da Silva, Danilo Grünig Humberto da Silva, Larissa Paola Rodrigues Venancio

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilana Luize Rocha SantanaDepartment of Biology, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, Sao Paulo 01049-010,Brazil.
Victoria Simões BernardoDepartment of Biology, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, Sao Paulo 01049-010,Brazil.
Edis Belini JuniorUniversidade Federal de Mato Grosso do Sul, CPTL/UFMS Três Lagoas, Mato Grosso do Sul 79600-080,Brazil.
Pâmela Lourdes Pereira da SilvaUniversidade Federal do Oeste da Bahia, Center for Biological and Health Science Barreiras, Bahia 47808-021,Brazil.
Danilo Grünig Humberto da SilvaDepartment of Biology, Universidade Estadual Paulista Julio de Mesquita Filho, São José do Rio Preto, Sao Paulo 01049-010,Brazil.ORCID https://orcid.org/0000-0002-5500-9403
Larissa Paola Rodrigues VenancioUniversidade Federal do Oeste da Bahia, Center for Biological and Health Science Barreiras, Bahia 47808-021,Brazil.ORCID https://orcid.org/0000-0003-1814-8954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell anemia (SCA) is a hemolytic anemia characterized by a chronic redox imbalance with few disease-modifying treatments available. In this study, we aimed to determine the influence of hydroxycarbamide (HC) treatment on the redox mechanisms of cellular adaptation in patients with SCA. We analyzed 10 patients treated (HC+) and 9 not treated (HC-). We evaluated, by RT-qPCR, the transcript levels of the transcription factors

Identifiers

PMID41476515
PMCPMC12750237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.