ArticleACS omega2025
ROS-Responsive Cationic Nanoparticles for Cyclosporine A Delivery in Dry Eye Disease: A Dual-Functional Nanotherapeutic Approach.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Dry eye disease (DED) is a prevalent ocular surface disorder characterized by tear film instability, chronic inflammation, and oxidative stress affecting 10-30% of the global population. A key driver of DED pathogenesis is the excessive reactive oxygen species (ROS), which disrupts corneal epithelial integrity, triggers apoptosis, and leads to a vicious cycle of inflammation and tissue damage. Current DED treatment involves immunosuppressants including cyclosporine A (CsA). However, conventional cyclosporine A (CsA) formulations suffer from poor solubility, rapid clearance, and nontargeted release. To address this problem, we developed CsA-loaded cationic nanoparticles (NPs) by coassembly of CsA with a cationic amphiphilic alternating copolymer P-(MS-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.