Evidence map›Paper›PMID 41476477›Full record

ArticleACS omega2025

Development and Validation of an Eco-Friendly HPLC Stability-Indicating Technique for Quantification of Atropine Sulfate and Benzyl Alcohol in Raw and Injectable Solutions.

Ahmed Sobhy Darwish, Sherief M Abdel-Raheem, Ahmed M A Meligy, Saad Ibrahim Al-Sultan, Mahmoud Kandeel, Wageh Sobhy Darwish

Abstract read
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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmed Sobhy DarwishFaculty of Science, Zagazig University, Zagazig 44519, Egypt.ORCID https://orcid.org/0009-0009-9000-3777
Sherief M Abdel-RaheemDepartment of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Al-Hofuf, Al-Ahsa 3198, Saudi Arabia.
Ahmed M A MeligyDepartment of Clinical Science, Central Lab, College of Veterinary Medicine, King Faisal University, P.O. Box: 400, Hofuf, Al-Ahsa 3198, Saudi Arabia.
Saad Ibrahim Al-SultanDepartment of Public Health, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Al-Hofuf, Al-Ahsa 3198, Saudi Arabia.
Mahmoud KandeelDepartment of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Hofuf, Al-Ahsa 3198, Saudi Arabia.ORCID https://orcid.org/0000-0003-3668-5147
Wageh Sobhy DarwishFood Hygiene, Safety and Technology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID https://orcid.org/0000-0002-4399-1401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study aimed to design and validate an affordable and ecologically conscious white HPLC stability-indicating method that can simultaneously detect atropine sulfate and benzyl alcohol in both bulk and injectable solutions of a generic medication from EIPICO, specifically for the registration of Trophovet injection, which is used in veterinary prescriptions. At a flow rate of 0.7 mL/min, the mobile phase consisted of 700 mL of 0.025 M potassium phosphate monobasic buffer solution with a pH of 3.5 and 300 mL of ethanol. Atropine sulfate concentrations ranged from 24 to 240 μg mL

Identifiers

PMID41476477
PMCPMC12750233

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.