Evidence map›Paper›PMID 41476462›Full record

ArticleACS omega2025

Lipid Armor Loaded with Doxylamine and Gemfibrozil for Glioblastoma Therapy: Particle Engineering and Multidimensional Two-Dimensional/Three-Dimensional Antitumor Efficacy.

Smita Dey, Sakshi Priya, Gautam Singhvi, Rajdeep Chowdhury, Shibasish Chowdhury

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Smita DeyDepartment of Biological Sciences, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
Sakshi PriyaIndustrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.ORCID https://orcid.org/0000-0002-8781-0297
Gautam SinghviIndustrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.ORCID https://orcid.org/0000-0002-9706-9244
Rajdeep ChowdhuryDepartment of Biological Sciences, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
Shibasish ChowdhuryDepartment of Biological Sciences, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.ORCID https://orcid.org/0000-0001-9290-3802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is an aggressive and highly treatment-resistant brain tumor with a poor prognosis and limited therapeutic options. Temozolomide (TMZ), the current standard chemotherapeutic agent, often fails due to acquired resistance and its high systemic toxicity at therapeutic doses. In our recent study, we repurposed two FDA-approved drugs, Doxylamine and Gemfibrozil, as potential alternatives to TMZ for GBM treatment. Both agents demonstrated superior efficacy in vitro, with lower IC

Identifiers

PMID41476462
PMCPMC12750267

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.