Trial reportJournal of Indian Prosthodontic Society2026
Microthreaded versus smooth implant collars: A randomized trial on peri-implant inflammatory cytokines and crestal bone levels.
Trial report in Journal of Indian Prosthodontic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
aimsTo evaluate the impact of implant collar design on peri implant inflammatory biomarkers and crestal bone levels over a 6-month period. SETTINGS AND
designThis pragmatic, randomized, parallel-group clinical trial was conducted at the Department of Prosthodontics and Crown and Bridge, Manav Rachna Dental College, between May 2023 and May 2024. MATERIALS AND
methodsThe study included 30 systemically healthy patients aged 20-60 years with a single missing tooth in the mandibular molar region. Patients were randomly assigned to two groups based on the implant collar design - smooth or microthreaded. Implants were placed following a standardized two stage surgical protocol. Peri-implant crevicular fluid was collected at the time of implant placement, 3 months, and 6 months postplacement to assess inflammatory biomarkers (interleukin-1 [IL-1β] and tumor necrosis factor alpha [TNF-α]) using ELISA. Peri-implant crestal bone levels were measured radiographically at the same intervals. STATISTICAL ANALYSIS USED: Statistical analysis was performed using the SPSS (version 21.0). The data were analyzed using appropriate statistical tests. P < 0.05 was considered statistically significant.
resultsIL-1β and TNF-α increased in both groups at the 3-month follow-up, reflecting a typical postsurgical inflammatory response and subsequently decreased at 6 months. The changes in cytokine levels were not significantly different (P > 0.05) between groups, suggesting a similar inflammatory response regardless of collar design. Crestal bone levels in implants with microthreaded collar design exhibited significantly lower loss (0.44 mm) compared to smooth collar implants (0.94 mm), with a statistically significant mean difference of 0.5 mm (P = 0.019). Correlation analysis revealed no statistically significant relationships between crestal bone levels and inflammatory markers at any time point.
conclusionAlthough both collar designs had a limited influence on the early peri-implant inflammatory response, but microthreaded collars were more effective in preserving crestal bone.
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