ArticleCardiovascular diabetology2025
Association between combined atherogenic and frailty index and cardiovascular events: evidence from the CHARLS cohort.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models for sarcopenia in older adults in China: a scoping review.Frontiers in medicine · 2026Pooled it
- Joint association of Insulin resistance and frailty index with incident ASCVD and MACE in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a multi-cohort study.Cardiovascular diabetology · 2026Observational
- Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study.Scientific reports · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Article
- Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Cardiovascular diabetology · 2026Article
- Associations of the atherogenic index of plasma and its modified indices with the incidence and progression of cardiovascular-liver-metabolic multimorbidity: a prospective cohort study from UK Biobank.Cardiovascular diabetology · 2026Article
- Associations of the combined C-reactive protein-triglyceride glucose index and frailty index in different dimensions with incident stroke among individuals with stages 0-3 cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Waist-to-height ratio modifies the association between cardiometabolic indices and incident carotid plaque: evidence from a Chinese cohort.Frontiers in nutrition · 2026Article
- Combined associations of the frailty index and CHG index with cardiometabolic multimorbidity: a longitudinal study from the CHARLS cohort.Frontiers in nutrition · 2026Article
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4 authors.
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Abstract
objectiveThe atherogenic index of plasma (AIP) is a marker of atherosclerosis, while frailty reflects cumulative physiological decline. However, the combined impact of AIP-frailty index (AIP-FI) has not been adequately explored. This study aimed to investigate the association between AIP-FI and the risk of cardiovascular disease (CVD), stroke, and heart disease.
methodsThis prospective cohort study included 6896 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS) without CVD, stroke, or heart disease at baseline. The Cox proportional hazard models and restricted cubic spline (RCS) analysis were applied to explore the association between AIP-FI with the risk of CVD, stroke, and heart disease.
resultsDuring a median follow-up period of 9 years, 1648 (23.9%) of CVD events, 548 (7.9%) of stroke events, and 1280 (18.6%) of heart disease events were recorded. Cox regression analysis revealed that each 1-unit increment in the AIP-FI was significantly associated with higher risk of CVD (HR: 2.95, 95% CI 2.15, 4.05), stroke (HR: 3.14, 95% CI 1.88, 5.26), and heart disease (HR: 2.72, 95% CI 1.06, 1.89, 3.92). The RCS revealed a significant positive nonlinear relationship between AIP-FI with the risk of CVD, stroke, and heart disease (all P-overall < 0.05, and all P for non-linear < 0.05).
conclusionsOur study demonstrated that higher AIP-FI was significantly associated with increased risk of CVD, stroke, and heart disease. By integrating metabolic and frailty information, AIP-FI offers an effective and accessible tool for cardiovascular risk assessment, supporting earlier prevention and intervention strategies in the middle-aged and elderly Chinese populations.
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