Evidence map›Paper›PMID 41476271›Full record

ArticleNature2026

Random heteropolymers as enzyme mimics.

Hao Yu, Marco Eres, Shayna L Hilburg, Philjun Kang, Tianyi Jin, Alexandra Grigoropoulos, Zhixia Li, Daniel M Loh, Ivan Jayapurna, Zhiyuan Ruan and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Multifaceted regulation of immune cells in radiation-induced pulmonary fibrosis: from mechanistic insights to targeted therapies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hao Yu *Departent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1594-769X
Marco Eres *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-9924-5707
Shayna L Hilburg *Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0825-7698
Philjun Kang *Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Tianyi JinDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-9974-2041
Alexandra GrigoropoulosDepartent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.
Zhixia LiDepartment of Nuclear, Plasma, and Radiological Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Daniel M LohDepartent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-4706-3829
Ivan JayapurnaDepartent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-1070-1014
Zhiyuan RuanDepartent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA.
Wen FuDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0744-4707
Feipeng YangAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Priya GaneshDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0000-4020-7100
Kali TosteDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA.
Shuni LiDepartment of Statistics, University of California, Berkeley, Berkeley, CA, USA.
Jinghua GuoAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-8576-2172
Haiyan HuangDepartment of Statistics, University of California, Berkeley, Berkeley, CA, USA.
F Dean TosteDepartment of Chemistry, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-8018-2198
R David BrittDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0889-8436
Y ZDepartment of Nuclear, Plasma, and Radiological Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-7339-8342
Alfredo Alexander-KatzDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. aalexand@mit.edu.ORCID 0000-0001-5554-1283
Ting XuDepartent of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA, USA. tingxu@berkeley.edu.ORCID 0000-0002-2831-2095

Funding

Alfred P. Sloan FoundationDivision of Chemical Sciences, Geosciences, and Bioscience of the US Department of Energy at LBNLNational Science Foundation Graduate Research FellowshipUS Department of Energy at LBNL
6 · The paper itself

Abstract

Despite successes in replicating the primary-secondary-tertiary structure hierarchy of protein, it remains elusive to synthetically materialize protein functions that are deeply rooted in their chemical, structural and dynamic heterogeneities

Indexed as

Biomimetic MaterialsEnzymesMetalloproteinsPolymersBiocatalysisCatalytic DomainCyclizationHydrophobic and Hydrophilic InteractionsModels, MolecularOxidation-ReductionEnzymesMetalloproteinsPolymers

Identifiers

PMID41476271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.