Evidence map›Paper›PMID 41476066›Full record

ArticleNature communications2025

A handheld photoacoustic microscopic probe integrating a transparent ultrasound transducer and a fiber scanner.

Mingyu Ha, Jaewoo Kim, Jihye Lee, Seonghee Cho, Dasom Heo, Minsu Kim, Joongho Ahn, Eunwoo Park, Joo Young Kweon, Yuri Kang and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mingyu Ha *Department of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Jaewoo Kim *Department of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-6585-9911
Jihye LeeDepartment of Chemistry, Pohang University of Science and Technology, Pohang, Republic of Korea.
Seonghee ChoMedical Device Innovation Center, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-1343-9827
Dasom HeoDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0003-0482-6822
Minsu KimDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0003-2883-8502
Joongho AhnMedical Device Innovation Center, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-5355-4125
Eunwoo ParkDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0001-7954-7911
Joo Young KweonDepartment of Medical Science and Engineering, School of Convergence Science and Technology, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0009-0006-0379-3984
Yuri KangDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Yong Joo AhnDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-0013-627X
Hyung Ham KimDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-6353-5550
Won Jong KimDepartment of Chemistry, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID http://orcid.org/0000-0002-4064-0999
Chulhong KimDepartment of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea. chulhong@postech.edu.ORCID http://orcid.org/0000-0001-7249-1257

Funding

National Research Foundation of Korea (NRF) 2020R1A6A1A03047902, 2020R1A6A1A03047902National Research Foundation of Korea (NRF) no. RS-2023-00212322, 2710076852National Research Foundation of Korea (NRF) no. RS-2025-00558651, 2710079568
6 · The paper itself

Abstract

Photoacoustic microscopy (PAM) has been widely used in biomedical studies to provide high-resolution 3D anatomical, functional, and molecular images of living subjects. While handheld PAM systems have been proposed to extend its applicability, it has proved challenging to achieve a compact device that combines fast imaging with high spatial resolution and signal to noise ratio. Here we demonstrate a handheld PAM probe integrating a fiber scanner and high-frequency transparent ultrasound transducer (TUT), called hPAM-TUT. The compact system (measuring 17 mm in diameter, with a 90 mm long rigid body) achieves high lateral and axial resolutions (7 and 47 μm, respectively), has a 2.6 mm diameter field of view, and delivers a single volumetric image in 1.5 s. In living rats, we used hPAM-TUT to visualize various abdominal organs, and in mice we used it to observe epinephrine-induced vascular changes and image the anatomy and functioning of lymphatic vessels after injection of Evans blue dye. Additionally, we successfully delineated murine vascular networks in early metastatic tumors. This handheld PAM probe shows promise for both clinical and research applications in such fields as dermatology, oncology, and intraoperative imaging.

Indexed as

MicroscopyPhotoacoustic TechniquesAnimalsImaging, Three-DimensionalLymphatic VesselsMiceRatsTransducersUltrasonography

Identifiers

PMID41476066
PMCPMC12881618

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.