ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025
Pulmonary valve replacement-related change in biventricular global function index in repaired tetralogy of Fallot.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundReduced biventricular global function index (BVGFI) is associated with adverse outcomes in repaired tetralogy of Fallot (rTOF). The change in BVGFI associated with pulmonary valve replacement (PVR) is unknown. This study aims to characterize BVGFI following PVR in rTOF and identify pre-PVR factors associated with severely depressed post-PVR BVGFI.
methodsSingle-center retrospective cohort study of rTOF patients with a cardiovascular magnetic resonance (CMR) examination within 1 year before and 2 years after their first PVR and no interval cardiac procedures (n = 133). CMR parameters between rTOF and normal controls (n = 136) were compared. BVGFI was categorized as normal (≥46.2), mild-moderately depressed (40.0-46.1), or severely depressed (<40.0). Pre- vs post-PVR changes and pre-PVR correlates of severely depressed post-PVR BVGFI were explored.
resultsWhen adjusted for age and sex, pre-PVR BVGFI was lower in patients with rTOF compared to controls (47.7 ± 0.6 vs 56.0 ± 0.5, p < 0.001), with 48% of rTOF patients having subnormal pre-PVR BVGFI. Overall, compared with pre-PVR values, mean BVGFI did not change after PVR (46.6 ± 7.7 vs 45.6 ± 6.7, p = 0.28), while right ventricular global function index declined from 49.6 ± 10.2 pre-PVR to 46.1 ± 9.0 post-PVR (p = 0.003). Among patients with normal pre-PVR BVGFI (n = 69), 64% remained normal, whereas 36% declined. Of those with severely depressed pre-PVR BVGFI (n = 24), 50% remained severely depressed, and only 4% achieved normalization of BVGFI after PVR. Factors independently associated with severely depressed post-PVR BVGFI were lower pre-PVR BVGFI, male sex, moderate or severe pulmonary regurgitation (PR), and higher left ventricular end-systolic volume index (LV ESVi). Type of pre-PVR hemodynamic load was not associated with the odds of severely depressed BVGFI post-PVR.
conclusionBVGFI is depressed in about half of rTOF patients pre-PVR and did not significantly change post-PVR, remaining stable in most patients. Lower pre-PVR BVGFI, male sex, moderate or severe PR, and higher LV ESVi are independently associated with severely depressed post-PVR BVGFI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.