Trial reportThe American journal of clinical nutrition2026
Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy 2 trial.
Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00427193 (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)
Who cites it
2 citing papers in PubMed.
- Use of Machine Learning to Identify Determinants of Habitual-Preformed Water Intake.The Journal of nutrition · 2026Trial
- Self-selected dietary intake and association with achieved caloric restriction in CALERIECritical reviews in food science and nutrition · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundComprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) was the first randomized controlled trial of calorie restriction (CR) on biomarkers of aging and cardiometabolic health in humans without obesity.
objectivesThe aim of this secondary data analysis was to evaluate diet quality and nutritional adequacy during a 2-y CR intervention among healthy adults in the CALERIE trial.
methodsCALERIE 2 was a multisite trial of healthy adults randomly assigned to 2 y of 25% CR or an ad libitum (AL) control condition. CR participants received extensive dietary education and support. Food records at baseline (BL) and months 6, 12, 18, and 24 were analyzed using Nutrition Data System for Research. Diet quality was evaluated using the Probability of Adequate Nutrient Intake (PANDiet) diet quality index, Healthy Eating Index (HEI), and Dietary Inflammatory Index (DII). Nutritional adequacy was defined using sex- and age-specific Estimated Average Requirement or Adequate Intake criteria for each nutrient.
resultsTwo hundred eighteen participants began the trial and are included in the analyses [143 CR, 75 AL; 69.7% females, age 38.1 ± 7.2 y (mean ± SD), BL body mass index: 25.1 ± 1.7 kg/m
conclusionsDiet quality improved and nutritional adequacy was maintained during a 2-y moderate CR intervention designed to enhance healthspan and comprised comprehensive nutrition counseling among healthy adults without obesity. The study was registered at clinicaltrials.gov as NCT00427193 (https://clinicaltrials.gov/study/NCT00427193?term=NCT00427193&rank=1).
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