Evidence map›Paper›PMID 41475424›Full record

ArticlemSystems2026

Lipopeptides and antibiotics from a marine

Hilary J Ranson, Yan-Song Ye, Valentina Z Petukhova, Abigail Green-Saxena, Ruolin He, Jiadong Sun, Bhaskar Godugu, Laura M Sanchez, Qihao Wu, David C Rowley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hilary J RansonDepartment of Biomedical & Pharmaceutical Sciences, The University of Rhode Island, Kingston, Rhode Island, USA.
Yan-Song YeDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Valentina Z PetukhovaDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Abigail Green-SaxenaDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Ruolin HeBioinformatics Group, Wageningen University, Wageningen, the Netherlands.
Jiadong SunDepartment of Biomedical & Pharmaceutical Sciences, The University of Rhode Island, Kingston, Rhode Island, USA.
Bhaskar GoduguDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Laura M SanchezDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0001-9223-7977
Qihao WuDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9677-9017
David C RowleyDepartment of Biomedical & Pharmaceutical Sciences, The University of Rhode Island, Kingston, Rhode Island, USA.ORCID 0000-0001-7808-1312

Funding

MALDI-TOF MS/IDBac to discover antibiotics from the Great Lakes sponge microbiomeR01GM125943 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MURPHY, BRIAN THACHER, SANCHEZ, LAURA MARGARET · 2018 to 2021
$2.1M
National Institute of Food and Agriculture 2019-67016-29868National Science Foundation MCB-2128044NIGMS NIH HHS R01 GM125943NIH HHS R01 GM125943
6 · The paper itself

Abstract

Bacteria produce a diverse range of specialized metabolites that influence the health and behavior of neighboring cells and, therefore, have potential applications in treating diseases. Deciphering the intended ecological functions of specialized metabolites is challenging due to the small scales at which these interactions occur and the complexity of unraveling simultaneous responses to multiple signals. In this study, we investigated the chemical interactions between two marine bacterial colonies, IMPORTANCE: Microbes communicate and compete using small molecules, yet linking specific metabolites to visible behaviors is difficult. We combine imaging mass spectrometry, genomics, analytical chemistry, and bioassays to decode an interaction between a marine

Indexed as

Anti-Bacterial AgentsBacillus pumilusLipopeptidesVibrio parahaemolyticusAntibiosisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnti-Bacterial AgentsLipopeptidesantibioticslipopeptidesMALDI TOF IMSmarine Bacillus

Identifiers

PMID41475424
PMCPMC12911350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.