Evidence map›Paper›PMID 41475275›Full record

ArticlePlacenta2026

Elucidating the role of ABC transporters in the placental efflux of (-)- Δ

Ankit Balhara, Xin Chen, Aditya R Kumar, Morgan E Wasickanin, Joshua W Monson, Jennifer R Damicis, Hillary J Kinsman, Nicholas Ieronimakis, Jashvant D Unadkat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ankit BalharaDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Xin ChenDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Aditya R KumarDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Morgan E WasickaninDepartment of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA, USA.
Joshua W MonsonDepartment of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA, USA.
Jennifer R DamicisDepartment of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA.
Hillary J KinsmanDepartment of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA.
Nicholas IeronimakisDepartment of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA, USA; Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, USA.
Jashvant D UnadkatDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA. Electronic address: jash@uw.edu.

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Understanding Fetal Exposure to Cannabinoids Through In Vitro and In Vivo StudiesP01DA032507 · NIDA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2013 to 2023
$12.4M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Drug Action, Metabolism and Kinetics Training GrantT32GM159560 · NIGMS · UNIVERSITY OF WASHINGTON · PI WILLIAM M ATKINS, Libin Xu · 2025 to 2026
$746k
NCATS NIH HHS TL1 TR002318NIDA NIH HHS P01 DA032507NIGMS NIH HHS T32 GM007750NIGMS NIH HHS T32 GM159560
6 · The paper itself

Abstract

We previously showed that THC is effluxed in the perfused human placenta cotyledons, but surprisingly this efflux was not inhibited by valspodar, a P-gp and BCRP inhibitor. P-gp and BCRP have multiple binding sites, and therefore THC may be binding to a transport site not blocked by valspodar. To test this hypothesis, we perfused human placenta cotyledons with THC in the absence and presence of a cocktail of P-gp and BCRP inhibitors. The inhibitor cocktail significantly increased the unbound maternal-to-fetal THC clearance index, indicating that P-gp and/or BCRP are likely involved in determining fetal THC exposure.

Indexed as

ATP-Binding Cassette TransportersDronabinolNeoplasm ProteinsPlacentaATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Biological TransportFemaleHumansMaternal-Fetal ExchangePregnancyABCG2 protein, humanATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2DronabinolNeoplasm ProteinsCocktail of ABC transporter inhibitorsFetal exposureMultiple binding sitesPerfused placentaPlacental transportTHC

Identifiers

PMID41475275
PMCPMC13021224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.