Evidence map›Paper›PMID 41475162›Full record

Observational studySleep medicine2026

Positive airway pressure therapy and cardiovascular events in obstructive sleep apnoea: an observational clinical cohort study.

Diego R Mazzotti, Aiyu Chen, Jaejin An, Joanie Chung, Jessica Arguelles, Brendan T Keenan, Greg Maislin, Bruno Saconi, Alexa J Watach, Henry Glick and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Diego R MazzottiDivision of Medical Informatics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA; Division of Pulmonary Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: droblesmazzotti@kumc.edu.
Aiyu ChenKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA.
Jaejin AnKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA; Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.
Joanie ChungKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA.
Jessica ArguellesKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA.
Brendan T KeenanDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Greg MaislinDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Bruno SaconiDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Alexa J WatachDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; School of Nursing, Department of Biobehavioral Health Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Henry GlickDepartment of Population Health Sciences, Geisinger, Danville, PA, USA.
Samuel T KunaDivision of General Internal Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, USA; Medicine Department, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Allan I PackDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Amy M SawyerSchool of Nursing, Department of Biobehavioral Health Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Dennis HwangKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA.
Jiaxiao ShiKaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, CA, USA.

Funding

MicroRNAs as Biomarkers for Obstructive Sleep ApneaP01HL160471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Allan I Pack · 2023 to 2026
$11.9M
NHLBI NIH HHS P01 HL160471
6 · The paper itself

Abstract

aimsStudies support the short-term benefit of continuous positive airway pressure (CPAP) therapy on cardiometabolic risk in adults with obstructive sleep apnoea (OSA). Evidence is limited on the benefits of CPAP for preventing acute major adverse cardiovascular events (MACE). This study aimed to assess the association between CPAP use and incidence of MACE in a longitudinal clinical cohort of adults with OSA at a large U.S. healthcare system.

methodsAdults with OSA (apnoea-hypopnoea index [AHI]≥5) were identified from Kaiser Permanente Southern California between 2018 and 2020 (N = 34,782). MACE was defined as first occurrence of myocardial infarction, stroke, unstable angina, heart failure or cardiovascular death, using validated electronic health record algorithms. CPAP use (h/night) was based on daily telemonitoring data. Inverse probability of treatment weighted Cox proportional hazards models stratified by OSA severity (mild [5≤AHI<15]), moderate-severe [AHI ≥15]), were used to assess associations between CPAP use and MACE.

resultsAmong individuals with moderate-severe OSA, those using CPAP <4 h/night (HR [95 % CI] = 0.53 [0.35-0.82]; p = 0.004) or ≥4 h/night (HR [95 % CI] = 0.46 [0.27-0.77]; p = 0.004) had lower MACE incidence compared to those not using CPAP. Increased CPAP use (in hours) was associated with lower MACE incidence in moderate-severe OSA (HR [95 % CI] = 0.90 [0.82-0.98]; p = 0.021). In individuals with mild OSA, CPAP use was not associated with lower MACE incidence.

conclusionCPAP use was associated with lower MACE incidence in adults with moderate-severe OSA. Treatment of moderate-severe OSA may have a positive impact on prevention of MACE.

Indexed as

Cardiovascular DiseasesContinuous Positive Airway PressureSleep Apnea, ObstructiveAdultAgedCohort StudiesFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedSeverity of Illness IndexCardiovascular diseaseContinuous positive airway pressureElectronic health recordsObstructive sleep apnoeaTreatment adherence

Identifiers

PMID41475162
PMCPMC13203992

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.