ArticleJournal of the American Chemical Society2026
A General Approach to Stereoregular Pseudo-Polysaccharides: Cationic Ring-Opening Polymerization of Monosaccharide Cyclic Thionocarbonates.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A sulfated chitosan-driven immune-ECM reprogramming strategy to break the vicious cycle of aged wound healing.Bioactive materials · 2026Article
- Regio-selective sulfation of heparin mimicking polymers defines in vivo activity.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Polysaccharide synthesis via chemical polymerization offers an efficient, facile, and cost-effective route to natural and mimetic polysaccharides with diverse biological and material properties. However, current polymerization-based approaches are largely restricted to low molecular weights (<50 kg/mol) and moderate stereoselectivity unlike their naturally derived counterparts where molecular weight is a key determinant of properties and function. Here, we report a robust strategy for constructing thiocarbonate-linked pseudo-polysaccharides via cationic ring-opening polymerization of readily accessible monosaccharide cyclic thionocarbonates. This polymerization proceeds with high reactivity and exclusive stereospecificity, affording pseudo-polysaccharides of high molecular weight (>500 kg/mol) across a variety of monosaccharide repeating units. Incorporation of a chain transfer agent (CTA) enables living polymerization, yielding polymers with predictable chain lengths and defined chain ends. Upon deprotection and sulfation, the resulting pseudo-polysaccharides exhibit strong fibroblast growth factor 2 (FGF2) binding and anticoagulant activity comparable to that of heparin, underscoring their potential as bioactive mimetics of biologically significant natural polysaccharides.
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