Observational studyPloS one2025
Association of perioperative fentanyl analog exposure with risk of psychiatric disorder in non-cardiac surgery: A 10-year retrospective study in a Korean tertiary hospital.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo evaluate the risk of developing psychiatric disorders within three years after non-cardiac surgery in patients exposed to fentanyl analogs versus other opioids.
designRetrospective observational study.
settingPostoperative period. PATIENTS: The study included 52,640adult patients who underwent non-cardiac surgery at Samsung Medical Center, Seoul, Korea, between January 2011 and June 2019.
interventionsPatients were divided into those exposed to fentanyl analogs and those exposed to other opioids. Propensity score matching and Cox regression analysis were used to compare the incidence of psychiatric disorders between the groups. MEASUREMENTS: Psychiatric outcomes, including depression, anxiety, stress-related disorders, substance use disorders, and psychotic disorders, were assessed. MAIN
resultsThe study included 52,640 patients, evenly split between the fentanyl and other opioid groups. Fentanyl exposure was associated with a higher incidence of composite psychiatric outcomes (hazard ratio [HR] 1.28 [1.13-1.46]; P < 0.001), including depression (HR 1.25 [1.08-1.45]; P = 0.003) and stress-related disorders (HR 1.45 [1.02-2.04]; P = 0.036). Subgroup analyses indicated increased risks in males, females, patients without alcohol history, and those not undergoing emergency surgeries.
conclusionsPerioperative fentanyl use is linked to a higher risk of psychiatric disorders compared to other opioids. These findings emphasize the need for careful use and monitoring of fentanyl in surgical patients, considering both immediate and long-term mental health effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.