ArticlePloS one2025
Whole-genome sequencing of Burkholderia glumae strains from Thailand reveals potential horizontal gene transfer with Burkholderia pseudomallei.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkholderia glumae is an emerging phytopathogen that causes bacterial panicle blight in rice and has been implicated in rare human infections. In Thailand, B. glumae and the human pathogen Burkholderia pseudomallei coexist in rice fields. Given the high genomic plasticity of Burkholderia species, including frequent genome rearrangements, variability in mobile genetic elements, and recombination events that facilitate horizontal gene transfer, there are concerns about the emergence of novel traits that may affect both plant and human health. In this study, we performed whole-genome sequencing and a comparative genomic analysis of 16 B. glumae strains isolated from rice fields across seven Thai provinces. Our phylogenomic analysis, based on core-genome single-nucleotide polymorphisms, revealed high genetic diversity and a polyclonal population structure, with evidence of a globally distributed clonal lineage. All isolates harbored plasmids and diverse prophage elements, which indicated extensive mobilome variability. A total of 572 putative horizontally transferred genes were identified. Most of these genes originated from unclassified or plant-associated Burkholderia species. Notably, two strains shared a chromosomal island that carried genes that were very similar to those found in B. pseudomallei. This genomic region contained genes associated with mobile genetic elements, phage defense, and a type VI secretion system, including genes that encode a PAAR domain-containing protein, a putative nuclease, and an immunity protein. Our findings highlight the genomic heterogeneity of B. glumae in Thailand and provide evidence of interspecies horizontal gene acquisition from human pathogenic B. pseudomallei. The presence of B. pseudomallei-derived genes in B. glumae chromosomes underscores the potential for genetic exchange in shared environmental niches, which could affect the evolutionary dynamics and pathogenicity of B. glumae. Hence, our findings also emphasize the critical need for environmental surveillance and genome-based monitoring to track emerging genomic combinations relevant to both plant and human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.