Evidence map›Paper›PMID 41474651›Full record

ArticleEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes2026

Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.

Umit Akin Dere, Fatma Altintas, Baris Albuz, Nazli Çil, Pelin Kuzucu, Esin Avci, Hande Senol, Ahmet Koluman, Mehmet Erdal Coskun

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Article in European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Umit Akin DereDepartment of Neurosurgery, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Fatma AltintasDepartment of Biomedical Engineering, Faculty of Technology, Pamukkale University, Denizli, Turkey.
Baris AlbuzDepartment of Neurosurgery, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Nazli ÇilDepartment of Histology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Pelin KuzucuDepartment of Neurosurgery, Faculty of Medicine, Gazi University, Ankara, Turkey, pelincolak@gazi.edu.tr.
Esin AvciDepartment of Medical Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Hande SenolDepartment of Biostatistics, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Ahmet KolumanDepartment of Biomedical Engineering, Faculty of Technology, Pamukkale University, Denizli, Turkey.
Mehmet Erdal CoskunDepartment of Neurosurgery, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used separately, their combined in vivo effects remain insufficiently investigated. This experimental study presents the first results on a composite wound dressing integrating PRP, rich in growth factors, with electrospun polyvinyl alcohol (PVA) nanofibers, a biocompatible and stable polymer.

methodsFull-thickness skin defects (1 × 1 cm2) were created in 21 adult female Sprague-Dawley rats and divided into three groups: control, PVA, and PRP/PVA. Wound healing was assessed histologically and biochemically on days 7 and 14, including fibroblast growth factor-2 (FGF-2) measurement.

resultsThe PRP/PVA group showed enhanced epithelialization and angiogenesis compared to other groups (p < 0.05), along with higher FGF-2 levels.

conclusionThe relatively small sample size, absence of a PRP-only group, and short observation period limit the generalizability of these findings. Within these constraints, the results indicate a potential synergistic role of PRP and PVA scaffolds in promoting wound repair, supporting further studies with larger cohorts and standardized PRP preparation before clinical translation.

Indexed as

BandagesPlatelet-Rich PlasmaPolyvinyl AlcoholWound HealingAnimalsDisease Models, AnimalFemaleFibroblast Growth Factor 2NanofibersRatsRats, Sprague-DawleyFibroblast Growth Factor 2Polyvinyl AlcoholOpen wound healingPlatelet-rich plasmaPolyvinyl alcoholWound dressing

Identifiers

PMID41474651
PMCPMC12845524

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.