Evidence map›Paper›PMID 41474621›Full record

ArticleCell reports2026

Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development.

Xuan Xie, Angela M Thornton, Shalini Tanwar, Patricia Korty, Alexandria C Wells, Elisha Segrist, Ana Teijeiro, Claudia A Rivera, Danping Wei, Xi Chen and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Xuan XieLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: xxsabrina0408@outlook.com.
Angela M ThorntonLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Shalini TanwarLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Patricia KortyLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Alexandria C WellsLaboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Elisha SegristLaboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ana TeijeiroLaboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Claudia A RiveraLaboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Danping WeiLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Xi ChenLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jinfang ZhuLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Asya KhleborodovaIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Tom HillIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Tovah E MarkowitzIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Margery SmelkinsonBiological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Juraj KabatBiological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Tibor VeresBiological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Owen M SchwartzBiological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Francisco Otaizo-CarrasqueroGenomic Research Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Paul GardinaGenomic Research Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Amirhossein ShamsaddiniGenomic Research Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Craig MartensGenomic Research Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kyoungin ChoComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Cheng-Chao LinComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jaspal S KhillanComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yelena LevinSequencing Facility, Illumina (CCR), National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ying WuAdvanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ethan M ShevachLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: eshevach@niaid.nih.gov.

Funding

Studies of the Function of Naturally Occurring and Adaptive T Regulatory CellsZ01AI000959 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI SHEVACH, ETHAN M. · 2006 to 2008
$5.1M
Intramural NIH HHS Z01 AI000959
6 · The paper itself

Abstract

Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability. We demonstrate that expression of Eos was limited to a subpopulation of thymus-derived, activated Tregs and is undetectable in resting or activated T conventional cells. Eos associates with Helios and Foxp3 and binds directly to the CD25 locus at a site identical to the Foxp3-binding site, thereby enhancing CD25 expression. Studies in heterozygous female mice demonstrate that Eos is critical for Treg survival and activation. Eos

Indexed as

HomeostasisIkaros Transcription FactorThymus GlandT-Lymphocytes, RegulatoryAnimalsCell MovementDendritic CellsDNA-Binding ProteinsFemaleForkhead Transcription FactorsInterleukin-2Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMiceMice, Inbred C57BLTranscription FactorsDNA-Binding ProteinsForkhead Transcription FactorsFoxp3 protein, mouseIkaros Transcription FactorInterleukin-2Interleukin-2 Receptor alpha SubunitTranscription FactorsZfpn1a2 protein, mouseautoimmune diseaseCD25CP: Immunologydendritic cellsEosHeliosIL-2MHC IIthymic recirculating TregsTreg precursorsTregsT regulatory cells

Identifiers

PMID41474621
PMCPMC12869356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.