ArticleDiscover oncology2025
The clinical efficacy evaluation of preoperative NHT treatment in laparoscopic radical prostatectomy: a systematic review and meta-analysis.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
objectiveThis study aims to systematically evaluate the impact of neoadjuvant therapy (NHT) on the efficacy and safety of laparoscopic radical prostatectomy (LRP).
methodsWe conducted a search of PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Database for cohort studies on neoadjuvant therapy combined with LRP for prostate cancer versus standard treatment for prostate cancer, up to February 2025. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies. Meta-analysis was performed using RevMan 5.4.1 software.
resultsA total of 14 studies were included. The results of the meta-analysis showed that compared to standard LRP, NHT combined with LRP can reduce the rate of positive surgical margins, biochemical recurrence rate, blood loss, and duration of catheterization. Subgroup analysis indicated that preoperative NHT combined with RALP demonstrated significant improvements in surgical time, blood loss, and positive surgical margins compared to traditional LRP.
conclusionNeoadjuvant therapy can improve tumor control outcomes for LRP, but may increase the risk of postoperative complications. NHT combined with RALP can be considered as a preferred treatment option in the surgical management of prostate cancer (PCa).
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