Evidence map›Paper›PMID 41474488›Full record

ReviewAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2026

Redefining Cardiac Sarcoidosis with Advanced Imaging and Therapeutic Strategies.

Claudio Tana, Vasilis Kouranos, Nicol Bernardinello, Cesare Mantini, Riccardo Scarpa, Francesco Cinetto, Dominique Israël-Biet, Paolo Spagnolo

Abstract readReview
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In one paragraph

Review in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudio TanaInternal Medicine Unit, Eastern Hospital, ASL Taranto, Via Mandonion 1, 74024, Manduria, TA, Italy. claudio.tana@yahoo.it.ORCID http://orcid.org/0000-0002-9162-7866
Vasilis KouranosRoyal Brompton and Harefield Hospitals, Part of Guy's and St Thomas' NHS Foundation Trust, London, UK.
Nicol BernardinelloRespiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Cesare MantiniDepartment of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Riccardo ScarpaRare Diseases Referral Center, Internal Medicine 1, Cafoncello Hospital, Treviso, Italy.
Francesco CinettoRare Diseases Referral Center, Internal Medicine 1, Cafoncello Hospital, Treviso, Italy.
Dominique Israël-BietFaculté de Médecine, Université de Paris Cité, Paris, France.
Paolo SpagnoloRespiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac sarcoidosis (CS) is an elusive, yet potentially life-threatening disease marked by granulomatous inflammation of the myocardium, which can lead to arrhythmias, heart failure, and sudden cardiac death. Although corticosteroids have long been the mainstay of treatment, the therapeutic landscape is rapidly evolving. Recent insights have underscored the role of alternative immunosuppressants and biologic agents in enhancing disease control while minimizing long-term toxicity. Advances in imaging, particularly cardiac magnetic resonance (CMR) and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) are transforming both diagnosis and follow-up, enabling earlier detection and personalized monitoring of therapeutic response. At the same time, arrhythmia management and device implantation, especially implantable cardioverter-defibrillators (ICDs), have become central to risk stratification and prevention of fatal outcomes. This review explores the latest developments in the management of CS, highlighting a paradigm shift toward integrated, multidisciplinary care. From immunomodulation to advanced imaging and electrophysiological strategies, we emphasize the importance of tailoring interventions to disease severity and patient risk. Special focus is given to high-risk cases and evolving criteria for heart transplantation, grounded in the most up-to-date clinical evidence.

Indexed as

CardiomyopathiesSarcoidosisDefibrillators, ImplantableFluorodeoxyglucose F18Heart TransplantationHumansImmunosuppressive AgentsMagnetic Resonance ImagingPositron-Emission TomographyFluorodeoxyglucose F18Immunosuppressive Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.