Evidence map›Paper›PMID 41474465›Full record

ReviewWorld journal of microbiology & biotechnology2025

Molecular weight regulation strategies in microbial synthesis of hyaluronic acid: current status and future perspectives.

Xiang Ma, Xinyue Fan, Shenglong Wang, Ziyi Zhao, Ziyao Zheng, Jun Li, Xueqian Dong, Hao Liu, Weixia Gao

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang MaKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Xinyue FanKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Shenglong WangKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Ziyi ZhaoKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Ziyao ZhengKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jun LiKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China.
Xueqian DongShandong Research and Design Institute of Food & Fermentation Industry, Jinan, Shandong, 250013, China.
Hao LiuKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China. liuhao@tust.edu.cn.
Weixia GaoKey Laboratory of Industrial·Fermentation Microbiology, Tianjin Key Laboratory of Industrial Microbiology, The College of Biotechnology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, 300457, China. gaoweixia@tust.edu.cn.

Funding

National Key Research and Development Program of China 2021YFC2103200
6 · The paper itself

Abstract

Hyaluronic acid (HA), a linear high-polymerization polysaccharide composed of repeating D-glucuronic acid and N-acetylglucosamine units, has gained significant attention due to its notable viscoelastic properties, high moisture retention capacity, and excellent biocompatibility. These unique characteristics have enabled its widespread applications across diverse sectors including biomedical engineering, advanced cosmeceuticals, and functional food industries. Emerging evidence indicates that the functional performance of HA is critically dependent on its molecular weight (Mw), with distinct biological roles and application domains being associated with high molecular weight HA (HMW-HA), low molecular weight HA (LMW-HA), and HA oligosaccharides (o-HA). Although substantial research efforts in recent years have been devoted to developing Mw regulation strategies for HA, a comprehensive synthesis of these methodologies remains scarce. This review systematically consolidates cutting-edge advancements in HA Mw modulation through four principal approaches: genetic engineering of HA synthases, enzymatic depolymerization techniques, metabolic pathway engineering, and optimization of fermentation parameters. Furthermore, we critically discuss current technological challenges and propose future research directions, establishing a methodological framework for the industrial-scale production of HA with precisely controlled Mw profiles.

Indexed as

BacteriaHyaluronic AcidFermentationHyaluronan SynthasesMetabolic EngineeringMetabolic Networks and PathwaysMolecular WeightHyaluronan SynthasesHyaluronic AcidHA synthaseHyaluronic acidHyaluronidasesMetabolic pathway engineeringMolecular weight

Identifiers

PMID41474465

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.