ArticleAnatolian journal of cardiology2025
Concomitant Percutaneous Left Atrial Appendage Closure and Transcatheter Aortic Valve Implantation: Double Hit Combo in Atrial Fibrillation.
Article in Anatolian journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with atrial fibrillation (AF) undergoing transcatheter aortic valve implantation (TAVI) often require longterm oral anticoagulation (OAC), which may not be appropriate for those at high bleeding risk. Performing left atrial appendage closure (LAAC) during TAVI can reduce the risk of thromboembolism while avoiding the need for prolonged anticoagulation.
methodsThis single-center study included 5 consecutive patients with severe aortic stenosis and AF who underwent same-session TAVI and LAAC between October 2024 and March 2025. All had contraindications to OAC or high bleeding risk. Procedural details and early outcomes were recorded. Technical success was defined according to Valve Academic Research Consortium-3 (VARC-3) (TAVI) and Munich/The Society for Cardiovascular Angiography & Interventions (SCAI) and the Heart Rhythm Society criteria (LAAC). Continuous variables are presented as mean ± SD or median interquartile range (IQR), and categorical variables as n (%).
resultsMean age was 75.6 ± 8.4 years; 40% were male. The median Society of Thoracic Surgeons score was 6.0% [IQR 5.5-7.0], median CHA₂DS₂-VA was 4 [4-5], and median hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile INR, elderly, drugs/alcohol concomitantly was 3 [3-4]. All patients received a Meril valve; LAAC devices included Amulet (n = 3) and LAmbre (n = 2). Technical success was achieved in all cases. There were no intra-periprocedural complications, major bleeding (Bleeding Academic Research Consortium ≥3), stroke/transient ischemic attack, or vascular complications. But Kidney Disease: Improving Global Outcomes stage 1 acute kidney injury was observed only in 1 (20%) patient. The median hospital stay was 4 [IQR 3-6] days.
conclusionIn this study, same-session TAVI and LAAC in AF patients with high bleeding risk were technically feasible and showed an acceptable shortterm safety profile. Larger, prospective studies with longer follow-up are needed to confirm these results.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.