Statistical Uncertainty of Inhalation Dose Coefficients in Consequence Management: Propagated Dose Uncertainty in ICRP 66 Human Respiratory Tract Model.

Reference inhalation dose models rely on deterministic biokinetics and reference computational phantoms, limiting their applicability to the variability present in population-specific exposures encountered in emergency response scenarios. This study introduces REDCAL, a Python-based computational framework developed to propagate uncertainty in inhalation dose coefficients using the International Commission on Radiological Protection (ICRP) Publication 66 Human Respiratory Tract Model. REDCAL integrates ICRP deposition and clearance models, systemic biokinetics, and governing physics principles, and leverages Sandia National Laboratories' Dakota toolkit for uncertainty quantification via Latin Hypercube Sampling. REDCAL was validated against DCAL, with biokinetic retention results differing by less than 1% and effective dose coefficients by less than 2% across all tested radionuclides. Stochastic sampling introduced variability in dose coefficients, with geometric standard deviations (GSD) in committed effective dose coefficients (CEDC) ranging from 1.0 to 1.5, based on lognormal distribution fits. Analysis demonstrated that variations in the activity median aerodynamic diameter (AMAD) notably influenced the computed CEDC values. Smaller particles (<1 µm) increased doses by 20-30% due to deeper lung deposition and prolonged retention for alpha emitting radionuclides, such as 241 Am and 239 Pu. Radionuclides with fast clearance, such as 133 I, demonstrated a dose reduction exceeding 50%, as AMAD increased beyond 5 µm due to upper airway deposition and rapid mucociliary clearance. The greatest GSD among the radionuclides reported in this study was for 241 Am. In most cases, the largest GSDs in the CEDC were associated with larger particle sizes, an expected outcome, as ICRP Publication 66 defines GSD in particle size as a function of AMAD, resulting in an extended tail of the lognormal distribution. The findings support improved inhalation dose assessments and enhance consequence management strategies for the U.S. Federal Radiological Monitoring and Assessment Center by quantifying uncertainty in dose coefficients and strengthening decision-making for emergency response scenarios.