SynthesisAnales del sistema sanitario de Navarra2025
Nightshift work and risk of breast and prostate cancer: a systematic review and meta-analysis, 2012-2023.
Synthesis in Anales del sistema sanitario de Navarra, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The circadian-melatonin axis in breast cancer metastasis: molecular mechanisms, organ-specific metastatic niches, and therapeutic opportunities.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe International Agency for Research on Cancer classifies night shift work as Group 2A, a probable human carcinogen. This study updates the evidence on the association between night shift work and the risk of breast and prostate cancer.
methodsSearches were conducted in PubMed and Web of Science. Case-control and cohort studies were included if they assessed night work as a risk factor for breast or prostate cancer, had =100 participants, provided full text in English or Spanish, scored =6 on the Newcastle-Ottawa Scale, and reported relative risks or odds ratio with 95% confidence interval. Heterogeneity and study quality were evaluated. Data synthesis followed PRISMA guidelines.
resultsTwenty-one studies including 586,890 participants were analysed. For breast cancer, significant association were found only in cohort studies, both overall (RR=0.82; 95%CI: 0.67-0.99; I2=91%) and for <10 years of night work (RR=0.75; 95% CI: 0.68-0.82; I2=0%). Average study quality was acceptable (score 7), although heterogeneity was substantial. For prostate cancer, case-control studies reported an OR of 1.14 (95%CI; 1.02-1.27; I2=25%). For exposures =10 years, both RR (2.20; 95%CI: 1.35-3.59) and OR (1.16; 95%CI: 1.03-1.30) were significant. Overall quality was moderate (score 6) with low heterogeneity (25%).
conclusionsWeak associations between night shift work and prostate cancer are observed in case-control studies and among individuals with =10 years of exposure, but no consistent association was found for breast cancer. These findings remain inconclusive and highlight the need for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.