Evidence map›Paper›PMID 41473953›Full record

ArticleCirculation research2026

Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.

Patrik Schelemei, Felix S R Picard, Yein Park, Philipp Wollnitzke, Harshal Nemade, Sebastian K Lechner, Dennis Mehrkens, Per Arkenberg, Anna C Köbele, Jan Wrobel and 26 more

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Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed

–field-weighted citation impact

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA.Circulation research · 2026
Article
The role of macrophages in aortic physiology and pathophysiology.Frontiers in immunology · 2026
Review
Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026
Review

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When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA.2026

5 · Who and what money

Authors and funding

36 authors.

Patrik SchelemeiDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-5532-5265

Felix S R PicardDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Yein ParkDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0007-8701-9888

Philipp WollnitzkeInstitute of Molecular Medicine III, (P.W., B.L.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-0116-546X

Harshal NemadeDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-2704-181X

Sebastian K LechnerDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0004-2980-0746

Dennis MehrkensDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-8578-0290

Per ArkenbergDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Anna C KöbeleDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Jan WrobelDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-1637-3413

Kristel Martinez LagunasDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-8306-6982

Elena WagnerDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-7433-671X

Henning GuthoffDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-0979-1190

Alexander HofDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-6554-8892

Khalia CummingsImmunology Center of Georgia, Augusta University, Augusta, GA (K.C., M.O.).ORCID 0009-0004-9226-6435

Muntadher Al ZaidiDepartment of Internal Medicine II-Cardiology, University Hospital Bonn, Bonn, Germany (M.A.Z., S.Z.).ORCID 0000-0002-3534-3121

Sebastian ZimmerDepartment of Internal Medicine II-Cardiology, University Hospital Bonn, Bonn, Germany (M.A.Z., S.Z.).ORCID 0000-0002-1531-2088

Joy RoyDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden (J.R., M.L.L.).ORCID 0000-0002-5645-1260

Moritz Lindquist LiljeqvistDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden (J.R., M.L.L.).ORCID 0000-0001-6821-6674

Dennis WolfCardiology and Angiology, Medical Center (D.W.), University of Freiburg, Freiburg, Germany.ORCID 0000-0003-1525-4348

Thomas RiffelmacherDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Wiebke IbingDepartment of Vascular and Endovascular Surgery (W.I., M.U.W. H.S.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Markus U WagenhäuserDepartment of Vascular and Endovascular Surgery (W.I., M.U.W. H.S.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-6597-1364

Hubert SchelzigDepartment of Vascular and Endovascular Surgery (W.I., M.U.W. H.S.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Bodo LevkauInstitute of Molecular Medicine III, (P.W., B.L.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-0005-125X

Ulrich FlögelExperimental Cardiovascular Imaging, Institute for Molecular Cardiology (U.F.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-7181-4392

Norbert GerdesDepartment of Cardiology, Pulmonology and Vascular Medicine (N.G.), Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-4546-7208

Mohammad KarimpourCenter for Molecular Medicine Cologne (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., M.K., A.M.H., G.S., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-7589-9984

Axel M HillmerCenter for Molecular Medicine Cologne (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., M.K., A.M.H., G.S., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Gerhard SengleCenter for Molecular Medicine Cologne (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., M.K., A.M.H., G.S., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-3932-1242

Remco T A MegensInstitute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany (R.T.A.M., C.W.).ORCID 0000-0001-9871-6696

Christian WeberInstitute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany (R.T.A.M., C.W.).ORCID 0000-0003-4610-8714

Marco OrecchioniImmunology Center of Georgia, Augusta University, Augusta, GA (K.C., M.O.).ORCID 0000-0002-3602-8510

Stephan BaldusDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-8259-1737

Martin MollenhauerDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3220-9269

Holger WinkelsDepartment of Cardiology, Heart Center (P.S., F.S.R.P., Y.P., H.N., S.K.L., D.M., P.A., A.C.K., J.W., K.M.L., E.W., H.G., A.H., T.R., S.B., M.M., H.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-1333-2031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbdominal aortic aneurysms (AAAs) are characterized by ECM (extracellular matrix) degradation and chronic vascular inflammation, with macrophages playing a key role. The mechanisms regulating macrophage activation in AAA remain incompletely understood. Vascular macrophages express Olfr2 (olfactory receptor 2), a GPCR (G-protein-coupled receptor) implicated in inflammation, but its role in AAA development is unknown.

methodsWe investigated the role of Olfr2 in AAA using PPE (porcine pancreatic elastase) infusion in Olfr2-deficient (

resultsMicroarray analysis revealed increased expression of the human

conclusionsOlfr2 regulates monocyte recruitment and macrophage-driven inflammation during AAA. Its genetic deletion or pharmacological inhibition protects against AAA, whereas receptor activation worsens the disease. Olfr2 represents a critical modulator of vascular inflammation and a potential therapeutic target in AAA.

Indexed as

Aortic Aneurysm, AbdominalCX3C Chemokine Receptor 1MonocytesAngiotensin IIAnimalsAorta, AbdominalDisease Models, AnimalHumansMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutAngiotensin IICX3C Chemokine Receptor 1Cx3cr1 protein, mouseaortic aneurysm, abdominalinflammationmonocytesreceptors, odorant

Identifiers

PMID41473953

DOI10.1161/CIRCRESAHA.125.326591

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