ArticleFrontiers in pediatrics2025
Ceftazidime-avibactam for the treatment of multidrug-resistant or extensively drug-resistant bacteria infection in preterm infants: case series study and literature review.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Objective: To evaluate efficacy and safety of ceftazidime-avibactam (CZA) in preterm infants with multidrug-resistant (MDR) or extensive drug-resistant (XDR) bacterial infections. Method: Retrospective analysis of clinical data was conducted on preterm infants who were monitored in NICU of Peking University of First Hospital for MDR/XDR infections between 2022 and 2025. A literature search was performed using PUBMED and WANFANG databases. Results: Six preterm infants (median gestational age 26 Conclusion: CZA alone or combined with aztreonam or colistin is effective and well-tolerated in critically ill preterm infants. However, the small sample size of patients limits the definitive conclusions about the safety profile of CZA, especially CNS risks. Further studies on the pharmacokinetics/pharmacodynamics and safety of CZA in preterm infants are warranted.
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