ReviewNeuro-oncology advances
Combined subtotal resection and stereotactic radiosurgery for large vestibular schwannomas: A systematic review and meta-analysis.
Review in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Large vestibular schwannomas (VSs), particularly Koos grade III-IV, often require a balance between tumor control and cranial nerve preservation. This meta-analysis evaluates outcomes of planned subtotal or near-total resection (STR/NTR) followed by stereotactic radiosurgery (SRS) and explores prognostic factors. Methods: Following PRISMA guidelines, a systematic review was conducted across four databases for studies published from January 2017 to January 2025, reporting outcomes of STR/NTR followed by SRS in large VSs. Pooled proportions for tumor control, facial nerve preservation (House-Brackmann grade I-II), and hearing preservation (Gardner-Robertson class I-II) were calculated using random-effects models. Heterogeneity, publication bias, and risk of bias were assessed. Meta-regression evaluated the impact of preoperative cranial nerve function and tumor characteristics. Results: Fourteen studies encompassing 934 patients were included. The pooled tumor control rate was 80%, with facial nerve function preserved in 85% and serviceable hearing in 43%. Meta-regression indicated that better preoperative HB and GR scores were significantly associated with superior outcomes ( Conclusions: STR/NTR followed by SRS is an effective treatment for large VSs, optimizing tumor control while enhancing facial nerve and hearing preservation compared to GTR alone. Patients with favorable preoperative function benefit most. Cystic tumors may require closer follow-up due to increased recurrence risk.
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