Evidence map›Paper›PMID 41473737›Full record

ArticleBioMed research international2025

Functional and Structure Prediction of Hypothetical Proteins From

Mutaz Mohammed Abdallah, Ruaa Abdalla Ibrahim Suliman, Yousra Tagelsir Ahmed, Mawada Yahia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mutaz Mohammed AbdallahDepartment of Microbiology, College of Life Sciences, Northeast Forestry University, Harbin, Heilongjiang, China, nefu.edu.cn.ORCID https://orcid.org/0009-0009-6204-458X
Ruaa Abdalla Ibrahim SulimanSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, tju.edu.cn.ORCID https://orcid.org/0009-0006-7849-2545
Yousra Tagelsir AhmedMicrobiology Department, Faculty of Medical Laboratory Science, University of Alzaiem Alazhari, Khartoum, Sudan.ORCID https://orcid.org/0009-0007-5130-1734
Mawada YahiaDepartment of Basic Sciences, Faculty of Dental Medicine and Surgery, National University, Khartoum, Sudan, inu.ac.kr.ORCID https://orcid.org/0000-0001-7021-0036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: The genome of Results: EUJ18943.1 (136 aa) and EUJ18676.1 (206 aa) are stable, hydrophilic proteins with acidic isoelectric points. BLASTp identified EUJ18943.1 as homologous to Imm48 immunity proteins and EUJ18676.1 as a GyrI-like detoxification protein. Both showed alpha-helix-rich secondary structures, with high-confidence AlphaFold3 models (pTM scores: 0.87 and 0.94). Structural validation confirmed the model quality. Virulence prediction tools classified both as potential virulence factors. Active sites were predicted by PrankWeb and ProBiS, identifying kanamycin A (score: 2.32) and streptomycin (score: 2.10) as top ligands. AutoDock v4.5.6 revealed strong binding affinities ( Conclusion: This study provides the first in silico structural and functional characterization of two HPs from

Indexed as

Bacterial ProteinsComputational BiologyListeriaBinding SitesGenome, BacterialMolecular Docking SimulationVirulenceBacterial ProteinsAlphaFold3bioinformaticsGyrI-like detoxificationhypothetical proteinImm48 immunityListeria aquaticamolecular dockingprotein–protein interactions

Identifiers

PMID41473737
PMCPMC12745843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.