ArticleOncology letters2026
A prognostic model for human papillomavirus-negative head and neck squamous cell carcinoma based on a novel ferroptosis-related gene signature: Development, validation and elucidation of its relationship with the immune microenvironment.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Head and neck squamous cell carcinoma (HNSCC) can be categorized as human papillomavirus (HPV)-positive or -negative. The present study explored the potential prognostic value of ferroptosis-related genes (FRGs) and their impact on the tumor immune microenvironment in HPV-negative HNSCC compared with HPV-positive HNSCC, based on data from The Cancer Genome Atlas online database. The bioinformatics analysis results were then verified through cell culture and histological analyses. The prognostic model was developed by evaluating the correlations between prognostic value and the expression of FRGs in HPV-negative HNSCC. This was based on differential analysis of data from The Cancer Genome Atlas between the HPV-negative and -positive patient subgroups. The relationships of the identified hub FRGs with immune cell infiltration were determined by CIBERSORT R scripts for the HPV-negative subgroup. Tribbles pseudokinase 3 (TRIB3) expression in both HPV-negative and -positive HNSCC cells was verified by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemistry. The role of TRIB3 in mediating ferroptosis in both HPV-positive and -negative cells was validated by transmission electron microscopy and intracellular Fe
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