Evidence map›Paper›PMID 41473659›Full record

SynthesisFrontiers in aging neuroscience2025

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson's disease: a network meta-analysis of 23 RCTs.

Dongyue Li, Xinyu Lin, Haojie Li, Jian Zhou

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongyue LiSchool of Physical Education, Guangzhou University, Guangzhou, China.
Xinyu LinSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Haojie LiSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Jian ZhouSchool of Physical Education, Guangzhou University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Parkinson's disease (PD) has become the fastest-growing neurological disease worldwide. This network meta-analysis evaluated the efficacy of transcranial stimulation combined with four rehabilitation approaches for improving gait and motor function in Parkinson's disease. Methods: We systematically searched seven databases: PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang. Data from 23 randomized controlled trials ( Results: (1) For gait outcomes, Dual-Task Training showed optimal efficacy for improving stride length (SUCRA = 100%) and velocity (86.5%), while Exercise Rehabilitation best improved cadence (100%). (2) For motor function, Conventional Rehabilitation demonstrated superior improvement in the Timed Up and Go test (100%), and Dual-Task Training showed advantages in Unified Parkinson's Disease Rating Scale Part III scores (85.1%). All combined interventions significantly outperformed the control groups ( Conclusion: The results support the use of personalized rehabilitation strategies: Dual-Task Training for patients with stride deficits and prominent motor symptoms, Exercise Rehabilitation for cadence improvement, and Conventional Rehabilitation for enhancing general mobility. These findings provide evidence-based guidance for optimizing neurorehabilitation protocols in the management of Parkinson's disease.

Indexed as

combined exercise therapygaitmotorParkinsonrehabilitationtranscranial stimulation

Identifiers

PMID41473659
PMCPMC12745421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.