Evidence map›Paper›PMID 41473499›Full record

ArticlePrzeglad gastroenterologiczny2025

Corticosteroid-induced mood changes in systemic autoimmune diseases: a multicentric study.

Mohammed Mahmoud Hamouda, Mohammed Abdel-Hassib, Hossam Shabana, Feras Almarshad, Omima Sayed Mohammed, Hazem S Ayoub, Himayat Ullah, Hani Ismail Hamed, Sherein M Alnabawy, Mohamed Abdel-Samiee and 1 more

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Article in Przeglad gastroenterologiczny, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammed Mahmoud HamoudaDepartment of Psychiatry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohammed Abdel-HassibDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hossam ShabanaDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Feras AlmarshadDepartment of Internal Medicine, College of Medicine, Shaqra University, Saudi Arabi.
Omima Sayed MohammedDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hazem S AyoubDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Himayat UllahDepartment of Internal Medicine, College of Medicine, Shaqra University, Saudi Arabi.
Hani Ismail HamedDepartment of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Sherein M AlnabawyInternal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Mohamed Abdel-SamieeNational Liver Institute, Menoufia University, Shebin El-Kom, Egypt.
Safaa Mahmoud HammoudaDepartment of Psychiatry, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Major depressive disorder (MD) is a significant mental health issue projected to become the leading contributor to the global burden of disease by 2030. MD substantially increases between teenage years and early adulthood. In addition, 25% of mood disorders manifest by 18 years old and 50% by age 30. Prior research investigated the relationship between the administration of corticosteroids and the onset of depression, revealing notable depressive symptoms and occurrences of depression in individuals undergoing corticosteroid treatment. Aim: We aimed to determine the prevalence of depression following corticosteroid therapy among a cohort of patients who received corticosteroids. Material and methods: This cross-sectional study was carried out at various centers, including Al-Azhar University Hospitals, involving a cohort of 500 cases. Results: The results of the Beck Depression Inventory showed a significant increase across all questionnaire items following corticosteroid therapy. The mean total score was 6.02 ±2.05 before corticosteroid therapy and 11.28 ±7.94 after therapy, showing a significant increase ( Conclusions: The presence of depression and severity of depression were significantly higher after corticosteroid therapy compared to before therapy.

Indexed as

autoimmune diseasescorticosteroidsmood changessystemic

Identifiers

PMID41473499
PMCPMC12746582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.