Evidence map›Paper›PMID 41473481›Full record

ArticleIDCases2025

Geographic shift of Japanese spotted fever and diagnostic overshadowing by COVID-19 testing: A genetically confirmed northernmost case.

Hiroaki Hara, Jiro Kamiyama, Ryoichiro Kondo, Shintaro Furuya, Shigemasa Taguchi, Yasushi Shibue, Motohiko Ogawa, Yuki Hashimoto, Koji Kikuchi, Kazuya Kiyota

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroaki HaraSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.
Jiro KamiyamaSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.
Ryoichiro KondoSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.
Shintaro FuruyaSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.
Shigemasa TaguchiSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.
Yasushi ShibueYokohama City Minato Red Cross Hospital Department of Infectious Diseases, Yokohama City, Japan.
Motohiko OgawaNational Institute of Infectious Diseases, Shinjuku City, Tokyo, Japan.
Yuki HashimotoNational Institute of Infectious Diseases, Shinjuku City, Tokyo, Japan.
Koji KikuchiSaitama City Institute of Health Science and Research, Saitama city, Saitama, Japan.
Kazuya KiyotaSaitama Red Cross Hospital Advanced Emergency Medical Center, Saitama City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Japanese spotted fever (JSF), caused by Rickettsia japonica, typically presents with fever, rash, and eschar. While endemic to western and southern Japan, recent cases have emerged in urban, non-endemic areas. A 49-year-old man developed fever after returning from a work assignment in Yamagata Prefecture, a historically non-endemic region. Despite no respiratory findings, he tested positive for SARS-CoV-2 antigen and was initially treated as COVID-19. His condition deteriorated into multiorgan dysfunction, requiring intensive care. Physical examination revealed a diffuse rash and an eschar on the lower leg. Rickettsial infection was suspected, and intravenous minocycline was initiated. Rickettsia japonica was later confirmed by PCR and serology. This case represents the northernmost genetically confirmed JSF in Japan and emphasizes the importance of maintaining a broad differential diagnosis, particularly when COVID-19 test results conflict with clinical findings.

Indexed as

COVID-19Japanese spotted feverRickettsial diseaseSepsisTetracycline

Identifiers

PMID41473481
PMCPMC12747234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.