Evidence map›Paper›PMID 41473476›Full record

ArticleIDCases2025

Graded isavuconazonium sulfate challenge in a patient with hypersensitivity to fluconazole.

Mark Biagi, Michael Pierce, Wendy Harney, Otavio Pereira-Rodrigues, Geoffrey Tsaras

Abstract readCase Reports
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark BiagiDepartment of Pharmacy, UW Health Swedish American Hospital, Rockford, IL, USA.
Michael PierceDepartment of Pharmacy, UW Health University Hospital, Madison, WI, USA.
Wendy HarneyDepartment of Pharmacy, UW Health Swedish American Hospital, Rockford, IL, USA.
Otavio Pereira-RodriguesDepartment of Internal Medicine, Section of Infectious Diseases, UW Health Swedish American Hospital, Rockford, IL, USA.
Geoffrey TsarasDepartment of Internal Medicine, Section of Infectious Diseases, UW Health Swedish American Hospital, Rockford, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypersensitivity reactions to triazole antifungals are uncommonly reported and cross-reactivity between these agents is poorly understood. We describe our experiences in a patient who previously developed a full body rash after receiving fluconazole who was initially successfully challenged and treated with isavuconazole without experiencing any adverse effects and was later separately re-challenged and treated successfully with a full-course of isavuconazole 8 months later. She received a third course of isavuconazole approximately 10 months after her second course, and developed rash, chest tightness, dyspnea, and facial flushing.

Indexed as

CandidiasisFluconazoleHypersensitivityIsavuconazoleIsavuconazonium sulfateRechallenge

Identifiers

PMID41473476
PMCPMC12747225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.