Evidence map›Paper›PMID 41473401›Full record

ArticleFood science & nutrition2026

The Effects of Flaxseed Consumption on Frailty and Sarcopenia in Patients With Liver Cirrhosis: An Open-Labeled Randomized Controlled Clinical Trial.

Fereshteh Pashayee-Khamene, Azita Hekmatdoost, Fatemeh Haidari, Amir Anushiravani, Behzad Hatami, Amir Sadeghi, Kambiz Ahmadi-Engali, Bizhan Helli

Abstract read
In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fereshteh Pashayee-KhameneStudent Research Committee Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.ORCID https://orcid.org/0000-0002-5799-649X
Azita HekmatdoostDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0002-1944-0052
Fatemeh HaidariSchool of Health, Medical and Applied Sciences CQUniversity Brisbane Australia.
Amir AnushiravaniDigestive Oncology Research Center, Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran.
Behzad HatamiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0001-9635-4345
Amir SadeghiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran Iran.
Kambiz Ahmadi-EngaliDepartment of Statistics and Epidemiology, Faculty of Public Health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Bizhan HelliNutrition and Metabolic Disease Research Center, Clinical Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty and sarcopenia are common among patients with liver cirrhosis (LC), which can lead to a higher risk of several morbidities and mortality. The primary goal of this study was to explore the impact of flaxseed consumption on body composition, frailty and sarcopenia, as well as disease severity and inflammation in these patients. In this 12-week, open-labeled randomized clinical trial, we recruited fifty patients with LC who were randomly allocated to receive either flaxseed (30 g/d flaxseed powder) or no intervention. Body composition and anthropometric parameters, high-sensitive C-reactive protein (hs-CRP), the model for end-stage liver disease-Na (MELD-Na), frailty, sarcopenia, and muscle strength were assessed at the initiation and upon completion of the trial. After the study was completed, percent of body fat (PBF) and waist circumference (WC) decreased significantly in the flaxseed group when compared to the group's pre-intervention values (

Indexed as

body compositionflaxseedfrailtyliver cirrhosissarcopenia

Identifiers

PMID41473401
PMCPMC12745882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.